The Huisgen Reaction of Azomethine Ylide to Isatins: A Facile Synthesis of Spiro-oxindoles

Abstract

A facile and convenient synthesis of spiro-oxindoles, structural units of many bioactive natural products, via 1,3-dipolar cycloaddition reaction of azomethine ylide with isatins is described.

ylides - isatins - indoles - heterocycles - spiro compounds

References

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It is felt that in due recognition of the original contributions of Professor Rolf Huisgen in the development of 1,3-dipolar cycloadditions, which constitute a very important organic reaction, it is obligatory to call them Huisgen Reactions.

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